1p lsd

1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is a derivative and functional analogue of LSD and a homologue of ALD-52. It has been sold online as a designer drug since 2015.^{[1][2][3][4][5][6]} It modifies the LSD molecule by adding a propionyl group to the nitrogen molecule of LSD’s indole.

The effects profile of 1P LSD is not well defined in the scientific literature. It is generally thought to be comparable to that of LSD.^[11] Many anecdotal reports indicate that 1P-LSD has a slightly shorter duration than LSD in humans, with the majority of users stating that they cannot distinguish the qualitative effects of 1P LSD from LSD

The original synthesis date of 1P-LSD is unknown. Unlike most research chemicals, 1P-LSD has no record in the scientific literature before its emergence on the online research chemical market in 2015. It was marketed as a legal alternative to LSD alongside other novel lysergamides like ALD-52, ETH-LAD, and AL-LAD.

1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is a novel psychedelic substance of the lysergamide class. It is structurally related to LSD and other novel lysergamides like 1cP-LSD, 1B-LSD, and 1V-LSD. It is thought to produce its effects by stimulating serotonin receptors in the brain, although the precise mechanism is not known.

1P-LSD has been sold online as a research chemical (also called “designer drug”) since 2015, but the original synthesis date of 1P-LSD is unknown. Unlike most research chemicals, it has no documented record in the research literature before its emergence on the online research chemical market in 2015.^[1]

It was marketed as a legal alternative to LSD alongside other novel lysergamides like ALD-52, ETH-LAD, and AL-LAD. In 2019, it became part of a group of molecules studied by the French laboratory Caulredaitens.^{[citation needed]}

Subjective effects include geometric visual hallucinations, time distortion, enhanced introspection, conceptual thinking, euphoria, and ego loss. User reports indicate that the subjective effects of 1P-LSD are extremely similar to those of LSD. It is theorized to act as a prodrug for LSD

This hypothesis is supported by the results of a study that demonstrated 1P-LSD is metabolized to LSD in rats. This predicts a near-identical effect profile, likely differing mainly in its rate of absorption and duration. Its classical psychedelic effects and favorable tolerability has led it to become popular among novel substance users who use it interchangeably with LSD.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-LSD. It is presumed to have a similar toxicity and risk profile as LSD, although there are no formal studies that prove this. It is highly advised to use harm reduction practices if using this substance.

1P-LSD first appeared on the online research chemical market in January 2015.^[1] Although it was likely discovered in an academic setting, it is unknown who first synthesized 1P-LSD, as the substance does not appear in any academic literature pre-dating its arrival on the research chemical market.^[3]

Interestingly, the future usage of 1-alkylated lysergamide derivatives as a means to bypass controlled substance laws banning LSD as a precursor was foreseen in a DEA report from 1988:

Buy 1P LSD

1P LSD is a semisynthetic compound of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH₃CH₂CO- bound to an amino group.

1P LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.